A crucial part of the work of the School of Psychotherapy in St Vincent's University Hospital, Dublin is to represent the contribution which the psychoanalytic field can make to our understanding and treatment of psychopathology. This issue of The Letter Irish Journal for Lacanian Psychoanalysis carries the proceedings of a conference we held in 2016. The conference asked a question: What is Anxiety? Treatment Challenges - Psychiatric, Medical and Psychoanalytic Approaches in Dialogue.